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KMID : 0620920220540091502
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Experimental & Molecular Medicine
2022 Volume.54 No. 9 p.1502 ~ p.1510
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Olfactory marker protein regulation of glucagon secretion in hyperglycemia
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Oh Ju-Hun
Han Ye-Eon
Bao Ya Ru
Kang Chan-Woo
Koo Jae-Hyung
Ku Cheol-Ryong
Cho Yoon-Hee
Lee Eun-Jig
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Abstract
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The olfactory marker protein (OMP), which is also expressed in nonolfactory tissues, plays a role in regulating the kinetics and termination of olfactory transduction. Thus, we hypothesized that OMP may play a similar role in modulating the secretion of hormones involved in Ca2+ and cAMP signaling, such as glucagon. In the present study, we confirmed nonolfactory α-cell-specific OMP expression in human and mouse pancreatic islets as well as in the murine α-cell line αTC1.9. Glucagon and OMP expression increased under hyperglycemic conditions. Omp knockdown in hyperglycemic αTC1.9 cells using small-interfering RNA (siRNA) reduced the responses to glucagon release and the related signaling pathways compared with the si-negative control. The OMPlox/lox;GCGcre/w mice expressed basal glucagon levels similar to those in the wild-type OMPlox/lox mice but showed resistance against streptozotocin-induced hyperglycemia. The ectopic olfactory signaling events in pancreatic α-cells suggest that olfactory receptor pathways could be therapeutic targets for reducing excessive glucagon levels.
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KEYWORD
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Cell biology, Diabetes insipidus
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